Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of A. actinomycetemcomitans
Infection and Immunity Volume 74 Issue 12
Page 7014-7020
published_at 2006-12
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| File | |
| Title ( eng ) |
Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of A. actinomycetemcomitans
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| Creator |
Nishikubo Shuichi
Ikura Masae
Fujiwara Tamaki
Komatsuzawa Hitoshi
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| Source Title |
Infection and Immunity
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| Volume | 74 |
| Issue | 12 |
| Start Page | 7014 |
| End Page | 7020 |
| Abstract |
Clinical Actinobacillus actinomycetemcomitans produces cytolethal distending toxin (CDT) with titers varying from 102 to 108 U/mg. SNP analysis of the Cdt gene in clinical isolates identified a variation of single amino acid at residue 281 of CdtB, which significantly affected CDT toxicity by modulating chromatin degrading activity of CdtB.
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| NDC |
Medical sciences [ 490 ]
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
American Society for Microbiology
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| Date of Issued | 2006-12 |
| Rights |
Copyright (c) 2006 American Society for Microbiology.
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| Publish Type | Author’s Original |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0019-9567
[DOI] 10.1128/IAI.02063-05
[NCID] AA00673732
[PMID] 16982823
[DOI] http://dx.doi.org/10.1128/IAI.02063-05
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