Olopatadine attenuates the enhancement of capsaicin-evoked substance P release by bradykinin from cultured dorsal root ganglion neurons
European Journal of Pharmacology Volume 552 Issue 1-3
Page 78-82
published_at 2006-12-15
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| File | |
| Title ( eng ) |
Olopatadine attenuates the enhancement of capsaicin-evoked substance P release by bradykinin from cultured dorsal root ganglion neurons
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| Creator |
Tang He-Bin
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| Source Title |
European Journal of Pharmacology
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| Volume | 552 |
| Issue | 1-3 |
| Start Page | 78 |
| End Page | 82 |
| Abstract |
Olopatadine, a second-generation antihistamine, has recently been suggested to have an inhibitory effect on the tachykinin release from guinea-pig tracheobronchial smooth muscle preparation. In the present study, using a highly sensitive radioimmunoassay for substance P, we observed that olopatadine attenuated the enhancement of capsaicin-induced substance P release by bradykinin with an IC50 value of 12.5 μM, without any inhibitory effect on the substance P release induced by capsaicin, potassium or bradykinin from cultured dorsal root ganglion neurons. These data suggest that olopatadine may therefore be involved in the bradykinin-induced sensitization of the transient receptor potential vanilloid 1 in cultured dorsal root ganglion neurons.
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| Keywords |
Olopatadine
Substance P release
Dorsal root ganglion
Bradykinin
Capsaicin
Transient receptor potential vanilloid 1
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| NDC |
Medical sciences [ 490 ]
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
Elsevier
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| Date of Issued | 2006-12-15 |
| Rights |
Copyright (c) 2006 Elsevier Ltd.
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| Publish Type | Author’s Original |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0014-2999
[DOI] 10.1016/j.ejphar.2006.09.016
[NCID] AA00639687
[PMID] 17055483
[DOI] http://dx.doi.org/10.1016/j.ejphar.2006.09.016
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