Embryonic dermal condensation and adult dermal papilla induce hair follicles in adult glabrous epidermis through different mechanisms
Development, Growth and Differentiation Volume 48 Issue 2
Page 73-86
published_at 2006-02
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Title ( eng ) |
Embryonic dermal condensation and adult dermal papilla induce hair follicles in adult glabrous epidermis through different mechanisms
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Creator |
Inamatsu Mutsumi
Tochio Takumi
Makabe Aya
Endo Tetsuya
Oomizu Souichi
Kobayashi Eiji
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Source Title |
Development, Growth and Differentiation
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Volume | 48 |
Issue | 2 |
Start Page | 73 |
End Page | 86 |
Abstract |
Hair induction in the adult glabrous epidermis by the embryonic dermis was compared with that by the adult dermis. Recombinant skin, composed of the adult sole epidermis and the embryonic dermis containing dermal condensations (DC), was transplanted onto the back of nude mice. The epidermis of transplants formed hairs. Histology on the induction process demonstrated the formation of placode-like tissues, indicating that the transplant produces hair follicles through a mechanism similar to that underlying hair follicle development in the embryonic skin. An isolated adult rat sole skin piece, inserted with either an aggregate of cultured dermal papilla (DP) cells or an intact DP between its epidermis and dermis, was similarly transplanted. The transplant produced hair follicles. Histology showed that the epidermis in both cases surrounded the aggregates of DP cells. The epidermis never formed placode-like tissues. Thus, it was concluded that the adult epidermal cells recapitulate the embryonic process of hair follicle development when exposed to DC, whereas they get directly into the anagen of the hair cycle when exposed to DP. The expression pattern of Edar and Shh genes, and P-cadherin protein during the hair follicle development in the two types of transplants supported the above conclusion.
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Keywords |
placode
embryonic hairs
hair germs
EGFP-transgenic rats
hair cycle
hair follicles
recombinant skin
skin transplantation
nude mice
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NDC |
Biology [ 460 ]
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Language |
eng
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Resource Type | journal article |
Publisher |
Blackwell Publishing
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Date of Issued | 2006-02 |
Rights |
Copyright (c) 2006 Blackwell Publishing, Inc
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Publish Type | Author’s Original |
Access Rights | open access |
Source Identifier |
[ISSN] 0012-1592
[NCID] AA00627804
[PMID] 16512852
[DOI] 10.1111/j.1440-169X.2006.00848.x
[DOI] http://dx.doi.org/10.1111/j.1440-169X.2006.00848.x
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