Hiroshima Journal of Medical Sciences Volume 61 Issue 4
published_at 2012-12

Changes in Cardiovascular Risk Factors over a 24-Year Follow-Up Period : A Japanese Pediatric Cohort Study

Kuwabara Masahiko
Hirata Hiroko
Sugino Hirotoshi
Asaoka Katsushi
Kondo Haruyasu
Fujii Kazuo
Matsubara Hideki
Nakagawa Takashi
Horie Masanori
Ito Hitoshi
Matsumoto Haruyuki
Okamoto Takuhiro
fulltext
266 KB
HiroshimaJMedSci_61_85.pdf
Abstract
This study examined changes in body mass index (BMI), fasting blood sugar (FBS), total cholesterol (TC) and HDL-cholesterol (HDL-C) levels over a 24-year follow-up period in a pediatric cohort. An appropriate starting age for intervention to prevent cardiovascular diseases is still unclear. The subjects were 655 children, aged 10-12. A follow-up survey was conducted when the subjects reached ages 13-15, 16-18, and 35-45, respectively, and height, weight, and blood tests including FBS, TC and HDL-C were examined. Forty (6%) of these subjects participated. BMI at ages 35-45 were significantly higher than those at ages 10-12 (p < 0.0001), 13-15 (p < 0.001), and 16-18 (p < 0.001). TC levels at ages 35-45 were significantly higher than at ages 10-12 (p < 0.0001), 13-15 (p < 0.0001), and 16-18 (p < 0.0001). BMI at the end of the follow-up (ages 35-45) had a significant correlation with BMI at ages 13-15 (R = 0.38, p = 0.041) and 16-18 (R = 0.41, p = 0.049). TC and HDL-C values at the end of the follow-up had a significant correlation with those at ages 10-12 (R = 0.55, p = 0.0004; R = 0.55, p = 0.016), 13-15 (R = 0.35, p = 0.045; R = 0.42, p = 0.015), and 16-18 (R = 0.47, p = 0.019; R = 0.44, p = 0.028). These results may suggest that intervention for children in Japan with cardiovascular risk factors should be initiated in the early years of life.
Keywords
Asa Cohort Study
Cardiovascular risk factor
Follow-up study
BMI
Rights
(c) Hiroshima University Medical Press.