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Hiroshima Journal of Medical Sciences Volume 32 Issue 2
published_at 1983-06
Effect of M Protein of Streptococcus pyogenes on Macrophage Functions
Streptococcus pyogenes の M protein のマクロファージ機能に及ぼす効果
Saito Hajime
Tomioka Haruaki
Sato Katsumasa
Watanabe Takashi
Abstract
Streptococcal M protein was studied to ascertain its effect on macrophage functions such as oxidative metabolism, phagocytosis, and microbicidal activity. No significant stimulating activity of M protein against macrophage functions such as H2O2 or O2- releasing ability in response to phorbol myristate acetate triggering was noted. M protein did not enhance the macrophage-mediated host risistance to infection with Listeria monocytogenes. However, macrophages elicited with M protein showed a somewhat more enhanced phagocytic activity than did the resident macrophages.
About This Article
Keywords
M protein
Streptococcus pyogenes
Macrophage Junction
Other Article
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