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ID 46494
本文ファイル
著者
Sukhdorj, Elbegzaya
Nakamura, Ryuji
Yanabe, Kensuke
Hirano, Hiroki
Hirano, Harutoyo
Yoshizumi, Masao 大学院医歯薬保健学研究科(医) 広大研究者総覧
Tsuji, Toshio 大学院工学研究科 広大研究者総覧
Kawamoto, Masashi 大学院医歯薬保健学研究科(医) 広大研究者総覧
キーワード
Photoplethysmogram
Anesthesia
Nociceptive reflex
NDC
医学
抄録(英)
A specific and reliable method for monitoring analgesia during general anesthesia is urgently required. Previously, we introduced a method that indicates arterial mechanical properties for estimating arterial wall stiffness (K). However, whether the response of K actually indicates changes in remifentanil target concentrations under continuous surgical stress, is unclear. Thus, we aimed to evaluate how K responds to different remifentanil target concentrations.
This prospective study enrolled 30 patients who underwent laparoscopic colectomy. The patients received 3 different effect-site concentrations (2, 4, and 6 ng/ml) of remifentanil 3 times during the study period. The K values at 4-ng/ml administration were used as control values (Kcontrol). K values at 6-ng/ml administration (K6ng) and those at 2-ng/ml administration (K2ng) were normalized by dividing them by the control values. The results showed that K responded to the changes in remifentanil concentration, significantly decreasing at 6-ng/ml remifentanil effect-site concentration and increasing at 2-ng/ml concentration. The stress response at low analgesia was higher than that at high analgesia, and, as predicted, normalized K2ng was significantly greater than normalized K6ng. In conclusion, we found that K is a sensitive stress response monitor and dynamically responds to changes in remifentanil concentration in invasive stimulation during laparoscopic colectomy.
掲載誌名
Hiroshima Journal of Medical Sciences
67巻
3号
開始ページ
55
終了ページ
61
出版年月日
2018-09
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright (c) 2018 Hiroshima University Medical Press
部局名
医歯薬保健学研究科
病院
工学研究科
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