PREPARATION OF OPTICALLY ACTIVE 2,2－DISUBSTITUTED 5-HYDROXYCHROMENES BY ENZYMATIC RESOLUTION OF RACEMIC ESTERS
Heterocycles Volume 97 Issue 1
Page 604-611
published_at 2018-05-18
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| File | |
| Title ( eng ) |
PREPARATION OF OPTICALLY ACTIVE 2,2－DISUBSTITUTED 5-HYDROXYCHROMENES BY ENZYMATIC RESOLUTION OF RACEMIC ESTERS
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| Creator |
Kainuma Mika
Yamada Ai
Katakawa Kazuaki
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| Source Title |
Heterocycles
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| Volume | 97 |
| Issue | 1 |
| Start Page | 604 |
| End Page | 611 |
| Abstract |
Enzymatic kinetic resolution of racemic esters of 2,2-disubstituted 5-hydroxychromenes was examined. Transesterification of acetate using Amano Lipase PS in the presence of t-BuOH was most effective to give the corresponding optically active acetate in 18% yield and 95% ee. The absolute configuration of the acetate was determined as R based on the conversion to teretifolione B with natural absolute configuration.
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| NDC |
Medical sciences [ 490 ]
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
The Japan Institute of Heterocyclic Chemistry
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| Date of Issued | 2018-05-18 |
| Rights |
Copyright (c) 2018 The Japan Institute of Heterocyclic Chemistry
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| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0385-5414
[ISSN] 1881-0942
[DOI] 10.3987/COM-18-S(T)45
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