High Prevalence of Caecal Dysplasia in Wistar/Furth Substrain Rats
Hiroshima Journal of Medical Sciences Volume 32 Issue 3
Page 295-299
published_at 1983-09
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| File | |
| Title ( eng ) |
High Prevalence of Caecal Dysplasia in Wistar/Furth Substrain Rats
|
| Title ( jpn ) |
Wistar/Furth 亜系ラットに認められた盲腸部異型上皮について
|
| Creator |
Naito Masashi
Naito Yukiko
Watanabe Hiromitsu
Ito Akihiro
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 32 |
| Issue | 3 |
| Start Page | 295 |
| End Page | 299 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Offspring of spontaneous colon tumor prone rats (WF/O) bred in our laboratory developed tumors in a very low incidence (less than 0.2 %), but about half of these rats had dysplastic epithelium with frequent erosion in the caecum. In nine animals (4.4%) submucosal glands of the caecum were observed. These dysplasia accompanied inflammatory cell reactions and regional lymph nodes were enlarged and packed with many plasma cells. Hybrid of WF/O rats and other inbred Long-Evans strain (LE) rats, having no dysplastic lesion of the caecum, had caecal dysplasia in a low incidence (10%). These data suggest that genetic factor(s) play an important role in the occurrence of caecal dysplasia in WF/O rats. These changes may be a precondition to the spontaneous occurrence of tumors in the proximal portion of the ascending colon with the aid of promoting factor(s).
|
| Keywords |
Caecal dysplasia
Spontaneous colon tumor
Rats
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1983-09 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6643108
|
