Intractable Gastrointestinal Bleeding from Angiodysplasia in a Patient of Bernard-Soulier Syndrome : Report of a Case

Okita Riki

Hihara Jun

Konishi Kazuo

Osaki Akihiko

Yoshida Kazuhiro

Yamaguchi Yoshiyuki

Toge Tetsuya

Fujimura Kingo

Iwata Takashi

Sawamura Akihiro

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

We herein report a case of gastrointestinal bleeding induced by angiodysplasia of the cecum in a case of Bernard-Soulier syndrome with recurrent breast cancer. In spite of endoscopic hemostatic therapy and interventional embolization, she had repeated massive bleeding from the cecal lesion. In addition, she had chronic hepatitis C and progressive liver tumors metastasized from breast cancer, and she finally died of hepatic failure. There are four case reports in the literature describing Bernard-Soulier syndrome with gastrointestinal bleeding angiodysplasia. The reported cases benefited from hormonal, endoscopical hemostasis and surgical therapy. In our case, because of her terminal metastatic breast cancer, only conservative treatments were administered after the third bleed. Both the endoscopic hemostatic method and interventional embolization showed only a temporary effect. Surgical treatment should be considered if the general condition can tolerate a surgical procedure.

Bernard-Soulier syndrome

Gastrointestinal bleeding

Angiodysplasia

Interventional embolization

Breast cancer

医学 [ 490 ]

英語

Hiroshima University Medical Press

Hiroshima University Medical Press

[ISSN] 0018-2052

[NCID] AA00664312