Bone marrow derived mast cell acquire responsiveness to substance P with Ca2+ signals and release of leukotriene B4 via mitogen-activated protein kinase

Journal of Neuroimmunology Volume 181 Issue 1-2 Page 1-12 published_at 2006-12

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Title ( eng )	Bone marrow derived mast cell acquire responsiveness to substance P with Ca2+ signals and release of leukotriene B4 via mitogen-activated protein kinase
Creator	Okabe Tsutomu Hide Michihiro Hiragun Takaaki Morita Eishin Koro Osamu Yamamoto Shoso
Source Title	Journal of Neuroimmunology
Volume	181
Issue	1-2
Start Page	1
End Page	12
Abstract	Substance P (SP) selectively activates mast cells that reside in connective tissues. We studied the reactions of bone marrow-derived mast cells (BMMC) of three mouse strains, cultured with or without fibroblasts. BMMC co-cultured with fibroblasts, but not those cultured alone, increased intracellular Ca2+, released LTB4 and histamine in response to SP. PD098059 significantly inhibited the release of LTB4, but not histamine in all strains. SB203580 failed to reduce or slightly impaired the release of LTB4. These results suggest that mast cells undergo maturation under the influence of fibroblasts, acquiring the responsiveness to SP with Ca2+ signals and predominantly ERK-MAP kinase.
Keywords	Ca2+ signal Leukotriene B4 Mast cell Mitogen-activated protein kinase Substance P
NDC	Medical sciences [ 490 ]
Language	eng
Resource Type	journal article
Publisher	Elsevier B.V.
Date of Issued	2006-12
Rights	Copyright (c) 2006 Elsevier B.V.
Publish Type	Author’s Original
Access Rights	open access
Source Identifier	[ISSN] 0165-5728 [DOI] 10.1016/j.jneuroim.2006.07.011 [NCID] AA1045958X [PMID] 16952405 [DOI] http://dx.doi.org/10.1016/j.jneuroim.2006.07.011 isVersionOf