Inhibition by Long-term Fermented Miso of Induction of Pulmonary Adenocarcinoma by Diisopropanolnitrosamine in Wistar Rats
Hiroshima Journal of Medical Sciences Volume 52 Issue 1
Page 9-13
published_at 2003-03
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| File | |
| Title ( eng ) |
Inhibition by Long-term Fermented Miso of Induction of Pulmonary Adenocarcinoma by Diisopropanolnitrosamine in Wistar Rats
|
| Creator |
Shiraki Katsuhisa
Yano Raita
Otani Satoko
Mimeoka Akane
Watanabe Hiromitsu
|
| Contributors | 国立情報学研究所 |
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 52 |
| Issue | 1 |
| Start Page | 9 |
| End Page | 13 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
The present study was designed to investigate the effects of fermented miso in the diet on the development of lung tumors initiated by diisopropanolnitrosamine (BHP) in male Slc:Wistar rats. A total of 63 animals, 6 weeks of age, were divided into 4 groups and given BHP (2000 ppm) in their drinking water for 10 weeks. After the carcinogen treatment the rats were fed a normal control MF solid diet, or the same diet containing 100ng-term or short-term fermented miso for 12 weeks. The long-term fermented miso significantly reduced the number of lung tumors, adenocarcinomas and PCNA strongly positive tumors as compared with the short-term fermented miso. The present results thus indicate that dietary supplementation with long-term fermented miso could exert chemopreventive effects on lung carcinogenesis.
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| Keywords |
Lung tumor inhibition
BHP
Long-term fermented miso
Wistar rats
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 2003-03 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Date |
[Created] 2006-03-21
|
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
|
