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ID 17698
本文ファイル
著者
Okita, Riki
Saeki, Toshiaki
Takashima, Shigemitsu
Aogi, Kenjiro
Ohsumi, Shozo
キーワード
Breast cancer
Trastuzumab
Stereotactic radiosurgery (SRS)
Central nervous system (CNS) metastasis
NDC
医学
抄録(英)
We report two cases of central nervous system (CNS) metastases during systemic response to trastuzumab in combination with chemotherapy for refractory breast cancer. The patients responded to trastuzumab in combination with chemotherapy. During combination treatment, the patients developed cerebellar metastases. A follow-up computed tomography scan revealed that their diseases continued to respond outside the CNS. These cases suggest that the failure of trastuzumab to cross the blood-brain barrier may compromise its overall effectiveness and raises the possibility that CNS metastasis may become clinically more significant in patients receiving antibody-based therapies, including patients responding to therapy outside the CNS. Additionally, repeated stereotactic radiosurgery as gammaknife combination therapy synchronously with systematic trastuzumab-based therapy was useful for the treatment of metastatic breast carcinoma.
掲載誌名
Hiroshima Journal of Medical Sciences
54巻
1号
開始ページ
35
終了ページ
38
出版年月日
2005-03
出版者
Hiroshima University Medical Press
国立情報学研究所
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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