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ID 17695
本文ファイル
著者
Arcana, I Made
キーワード
Gamma-frailty model
Miso (fermented soy bean paste)
Poisson regression model
Radio protective effects
NDC
医学
抄録(英)
We consider multi-target models for use in analyzing data of the dose-response relationship. The target sizes we are concerned with here are both homogeneous, as assumed in the classical model, and heterogeneous, as simplified using geometric progression. We apply two models for establishing the multi-target models: a Poisson regression model constructed by assuming that the response variable Y follows Poisson distribution, and a gamma-frailty model as a Poisson mixture model derived by adding random common risks having a gamma distribution. Applying these models to experimental data relating the effects of miso fermentation-stages on the survival rate of cells of intestinal crypts of mice exposed to radiation yielded the result that there were substantial frailties associated with all miso fermentation-stages. Short-term and medium-term fermented miso provided similar effects, whereas long-term fermentation had the lowest relative risk value, indicating a significant protection of the crypts against exposure effects. A gamma-frailty model based on heterogeneous target size was more suitably applied when there were at least 3 dead stem cells having 10 target genes.
掲載誌名
Hiroshima Journal of Medical Sciences
54巻
1号
開始ページ
9
終了ページ
20
出版年月日
2005-03
出版者
Hiroshima University Medical Press
国立情報学研究所
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
原爆放射線医科学研究所
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