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ID 48138
本文ファイル
著者
Sasatani, Megumi 原爆放射線医科学研究所 広大研究者総覧
Satoh, Kenichi 原爆放射線医科学研究所
Yoshizumi, Masao 大学院医系科学研究科(医) 広大研究者総覧
キーワード
blood pressure
brain protection
hypertension, miso (Japanese soy bean paste)
SHRSP
stroke
抄録(英)
[BACKGROUND AND HYPOTHESIS] Soybean isoflavones have been shown to reduce the risk of cerebral infarction in humans according to epidemiological studies. However, whether intake of miso can reduce the incidence of stroke in animal models remains unknown. In this study, we investigated the effects of soybean paste (miso) in an animal model of stroke.
[METHODS] Stroke-prone spontaneously hypertensive rats (SHRSP) were fed a miso diet (normal diet 90%, miso 10%; final NaCl content 2.8%), a high salt diet (normal diet and NaCl 2.5%; final NaCl content 2.8%), or a low salt diet (normal diet; final NaCl content 0.3%).
[RESULTS] Kaplan–Meier survival curves revealed a significantly lower survival rate in the high salt group compared to the miso group (P = 0.002) and the low salt group (P ≤ 0.001). Large hemorrhagic macules were found in the cerebrum in the high salt group, whereas none were found in the other 2 groups. There were also fewer histological and immunohistochemical changes in the brain and kidneys in the miso group compared to the high salt group.
[CONCLUSION] Our results suggest that miso may have protective effects against stroke despite its high salt content.
内容記述
This work was supported by a grant-in-aid from the Central Miso Institute, Tokyo, Japan
掲載誌名
American Journal of Hypertension
31巻
1号
開始ページ
43
終了ページ
47
出版年月日
2017-07-31
出版者
Oxford University Press
ISSN
1941-7225
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright © 2017 American Journal of Hypertension, Ltd.
This document is the Accepted Manuscript version of a Published Work that appeared in final form in 'American Journal of Hypertension', copyright c American Journal of Hypertension after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1093/ajh/hpx129.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
関連情報URL
部局名
統合生命科学研究科
備考
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