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ID 48649
本文ファイル
著者
Nezu, Tomohisa 大学院医歯薬保健学研究科(医) 広大研究者総覧
Hosomi, Naohisa 大学院医歯薬保健学研究科(医) 広大研究者総覧
Anno, Kumiko 大学院医歯薬保健学研究院(薬)
Aoki, Shiro
Shimamoto, Akira 大学院医歯薬保健学研究科(薬)
Maruyama, Hirofumi 大学院医歯薬保健学研究科(医) 広大研究者総覧
Hayashi, Tomonori
Matsumoto, Masayasu 大学院医歯薬保健学研究院(医)
Tahara, Hidetoshi 大学院医歯薬保健学研究院(薬) 広大研究者総覧
キーワード
Endothelial dysfunction
Telomere lengths
Telomere G-tail lengths
White matter changes
抄録(英)
Background: The telomeric 3′-overhang (G-tail) length is essential for the biological effects of telomere dysfunction in vitro, but the association of length with aging and cardiovascular risk is unclear in humans. We investigated the association between the telomere G-tail length of leukocytes and cardiovascular risk, age-related white matter changes (ARWMCs), and endothelial function.
Methods: Patients with a history of cerebrovascular disease and comorbidity were enrolled (n = 102; 69 males and 33 females, 70.1 ± 9.2 years). Total telomere and telomere G-tail lengths were measured using a hybridization protection assay. Endothelial function was evaluated by ultrasound assessment of brachial flow-mediated dilation (FMD).
Findings: Shortened telomere G-tail length was associated with age and Framingham risk score (P = 0.018 and P = 0.012). In addition, telomere G-tail length was positively correlated with FMD values (P = 0.031) and negatively with the severity of ARWMCs (P = 0.002). On multivariate regression analysis, telomere G-tail length was independently associated with FMD values (P = 0.022) and the severity of ARWMCs (P = 0.033), whereas total telomere length was not associated with these indicators.
Interpretation: Telomere G-tail length is associated with age and vascular risk factors, and might be superior to total telomere length as a marker of endothelial dysfunction and ARWMC severity.
内容記述
This study was supported in part by research grants from the Smoking Research Foundation, the Tsuchiya Foundation, the Japan Science and Technology Agency, the Japan Heart Foundation, Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and JSPS KAKENHI Grants-in-Aid for Scientific Research (B) (Generative Research Fields).
掲載誌名
EBioMedicine
2巻
8号
開始ページ
960
終了ページ
967
出版年月日
2015-05
出版者
Elsevier B.V.
ISSN
2352-3964
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
関連情報URL
部局名
医歯薬学総合研究科
病院