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ID 48635
本文ファイル
著者
Okubo, Hirofumi 病院(医)
Kushiyama, Akifumi
Sakoda, Hideyuki
Nakatsu, Yusuke
Iizuka, Masaki
Taki , Naoyuki
Fujishiro, Midori
Kamata, Hideaki 大学院医歯薬保健学研究科 広大研究者総覧
Nagamachi, Akiko 原爆放射線医科学研究所 広大研究者総覧
Inaba, Toshiya 原爆放射線医科学研究所 広大研究者総覧
Nishimura, Fusanori
Katagiri, Hideki
Asahara, Takashi
Yoshida, Yasuto
Chonan, Osamu
Encinas, Jeffery
Asano, Tomoichiro 大学院医歯薬保健学研究科 広大研究者総覧
抄録(英)
Resistin-like molecule β (RELMβ) reportedly has multiple functions including local immune responses in the gut. In this study, we investigated the possible contribution of RELMβ to non-alcoholic steatohepatitis (NASH) development. First, RELMβ knock-out (KO) mice were shown to be resistant to methionine-choline deficient (MCD) diet-induced NASH development. Since it was newly revealed that Kupffer cells in the liver express RELMβ and that RELMβ expression levels in the colon and the numbers of RELMβ-positive Kupffer cells were both increased in this model, we carried out further experiments using radiation chimeras between wild-type and RELMβ-KO mice to distinguish between the contributions of RELMβ in these two organs. These experiments revealed the requirement of RELMβ in both organs for full manifestation of NASH, while deletion of each one alone attenuated the development of NASH with reduced serum lipopolysaccharide (LPS) levels. The higher proportion of lactic acid bacteria in the gut microbiota of RELMβ-KO than in that of wild-type mice may be one of the mechanisms underlying the lower serum LPS level the former. These data suggest the contribution of increases in RELMβ in the gut and Kupffer cells to NASH development, raising the possibility of RELMβ being a novel therapeutic target for NASH.
掲載誌名
Scientific Reports
6巻
開始ページ
20157
出版年月日
2016-01-28
出版者
Nature Publishing Group
ISSN
2045-2322
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
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関連情報URL
部局名
医歯薬保健学研究科
原爆放射線医科学研究所
病院