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ID 49954
本文ファイル
著者
YASUKAWA, Akihiro
NIHIRA, Hiromi
キーワード
Testis
Estrogen
Androgen production
NDC
医学
抄録(英)
The effects of diethylstilbestrol diphosphate (DESDP) on testicular steroidogenesis were investigated in patients undergoing orchiectomy for prostatic carcinoma.
In non-DESDP treated patients the concentration of cAMP in the spermatic venous blood was 17.8 ± 3.1 (SE) pmoles/ml, which increased to 343.3 ± 18.6 (SE) pmoles/ml 30 min after hCG (1,000 IU) injection into the testis. T increased gradually from the pretreated level of 26.5 ± 7.2 (SE) μg/dl at 50 min. A slight increase in DHT was observed after hCG injection. Ten days' injections of DESDP significantly reduced the responses of T and DHT to hCG and 20 days' injections decreased T and DHT responses as well as cAMP response to hCG.
These findings indicate that DESDP can directly suppress the hCG stimulated steroidogenesis and cAMP production in human testis in vivo. The inhibitory effects of DESDP on Leydig cell function are probably on T biosynthesis as well as on cAMP formation.
掲載誌名
Hiroshima Journal of Medical Sciences
36巻
1号
開始ページ
1
終了ページ
5
出版年月日
1987-03
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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