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ID 49983
本文ファイル
著者
FUJII, Hideaki
キーワード
Essential hypertension
Digitalis-like substance
Vascular reactivity to norepinephrine
Pressor response to norepinephrine
NDC
医学
抄録(英)
In order to clarify the role of a circulating digitalis-like substance in the pathogenesis of essential hypertension, short (intravenous) and long term (oral administration) effects of digoxin on the vascular reactivity to infused norepinephrine (NE) at a constant rate (0.22 μg/kg/min) were studied in normotensive male volunteers.
In 14 subjects 90 min after intravenous administration of digoxin, basal intraerythrocytic sodium concentration (ENa) before NE infusion was significantly increased due to inhibition of Na+, K+ ATPase activity in cell membrane by digoxin indicated as erythrocyte ouabain sensitive efflux rate constant (ERCos), and basal plasma NE concentration (PNE) was significantly increased. Basal hemodynamic parameters except for heart rate (HR) remained unchanged, but increases in mean blood pressure and total peripheral resistance during NE infusion (△MBP and △TPR) were significantly augmented. Increase in PNE during NE infusion (△PNE) tended to decrease. Intravenous administration of digoxin significantly augmented △MBP/ △PNE and △TPR/ △PNE as the parameters for the pressor response and vascular reactivity to NE from 3.81 ± 1.64 mmHg•ml•ng^-1 to 4.85 ± 2.12 mmHg•ml•ng^-1 and from 121 ± 75 dyne•sec•cm^-2•ng^-1 to 147 ± 61 dyne•sec•cm^-2•ng^-1, respectively.
In 14 subjects after 6 days oral administration of digoxin as well as intravenous administration of digoxin, basal ERCos was significantly inhibited and basal ENa was significantly increased. Basal PNE was unchanged, but △PNE was significantly decreased. Oral administration of digoxin also significantly augmented the pressor response and vascular reactivity to NE from 5.14 ± 1.70 mmHg•ml•ng^-1 to 6,25 ± 2.00 mmHg•ml•ng^-1 and from 130 ± 65 dyne•sec•cm^-2•ng^-1 to 176 ± 53 dyne•sec•cm^-2•ng^-1, respectively.
These findings suggest that the augmented pressor response to NE is caused by the enhanced vascular reactivity to NE through inhibition of Na+, K+ ATPase activity in cell membrane by digoxin. Thus, a circulating digitalis-like substance may play an important role in the pathogenesis of essential hypertension.
掲載誌名
Hiroshima Journal of Medical Sciences
36巻
2号
開始ページ
233
終了ページ
244
出版年月日
1987-06
出版者
Hiroshima Journal Medical Press
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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