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ID 49974
本文ファイル
著者
NAKAMOTO, Takahisa
OKADA, Mitsuo
NAKAMURA, Koji
NIHIRA, Hiromi
YASUKAWA, Akihiro
TAKENAKA, Ikumasa
NISHI, Nozomu
MATSUO, Yuhsi
WADA, Fumio
キーワード
Ornithine decarboxylase activity
Aging
Rat ventral prostate
Tissue dihydrotestosterone content
NDC
医学
抄録(英)
The age-related alteration of androgen dependency in ornithine decarboxylase (ODC) activity was examined in ventral prostate from: (1) intact rats aged 6, 10, 50 and 100W; (2) castrated rats aged 10 and 100W; (3) 10 and 100W rats castrated for 7 days before injection with testosterone propionate for up to 7 days. Tissue dihydrotestosterone (DHT) contents in ventral prostate from intact rats aged 10 and 100W were also measured. ODC activity of rat ventral prostate declined with aging. Castration resulted in rapid decline in ODC activity of young mature rats (l0W) and the activity was restored to normal value by the injection of testosterone propionate. On the other hand, the changes in ODC activity of old rats (100W) induced by castration and androgen replacement were significantly slower than those of young mature rats. In young mature rats, ODC activity was apparently correlated with prostatic DHT contents. Although prostatic DHT contents of old rats retained a similar level to young mature rats, no such correlation between ODC activity and tissue DHT content was observed.
These results showed androgen-sensitive nature of ODC activity. And the sensitivity might be affected by aging at a step by which androgen showed its action.
掲載誌名
Hiroshima Journal of Medical Sciences
36巻
2号
開始ページ
175
終了ページ
178
出版年月日
1987-06
出版者
Hiroshima Journal Medical Press
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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