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ID 49967
本文ファイル
著者
DAVIDKOVA, Tatiana Ivanova
FUJII, Kohyu
KIKUCHI, Hirosato
HORIBE, Mayumi
MUKAIDA, Keiko
SATO, Nobuyoshi
MORIO, Michio
キーワード
Anesthetics
volatile: sevoflurane
Biotransformation: fluorometabolites
Pharmacokinetics: excretion
Toxicity: metabolites
NDC
医学
抄録(英)
This study was designed to investigate the defluorination of sevoflurane in patients. Five patients, scheduled for orthopedic surgery, were administered sevoflurane for 60 min during NLA-nitrous oxide-oxygen. The end-tidal concentration of sevoflurane was adjusted at 0.6% throughout the entire inhalation period.
The serum concentration of inorganic F- increased significantly 15 min after the onset of inhalation and reached a plateau at 45 min with a mean value about 15 μM. The serum organic fluoride level increased significantly 45 min after the onset of inhalation and did not change significantly 4 hr later with a mean value of about 140 μM.
The elimination half-lives and rate constants were calculated from urinary data to be 2040 min and 0.00034 for inorganic fluoride and 1800 min and 0.00038 for organic fluoride respectively. The ratio organic/inorganic fluoride was calculated to be 2.3.
内容記述
This study was supported in part by a Grant-in-aid for Science Research from the Ministry of Education, Science and Culture of Japan.
掲載誌名
Hiroshima Journal of Medical Sciences
36巻
1号
開始ページ
99
終了ページ
104
出版年月日
1987-03
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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