このエントリーをはてなブックマークに追加
ID 49917
本文ファイル
著者
SUMII, Koji
UEMURA, Naomi
INBE, Akira
HARUMA, Ken
INABA, Yoshiro
TARI, Akira
YOSHIHARA, Masaharu
SEKITOH, Masaki
TOKUTOMI, Tadashi
KAJIYAMA, Goro
MIYOSHI, Akima
キーワード
Duodenal ulcer
Hyperpepsinogenemia I
Autosomal dominant inheritance
NDC
医学
抄録(英)
To clarify genetic factors involved in the familial aggregation of duodenal ulcer, serum pepsinogen I levels were determined by radioimmunoassay in patients with duodenal ulcer and their affected and unaffected relatives.
There existed relationship between an elevated pepsinogen I level and susceptability of duodenal ulcer, and the familial aggregation of duodenal ulcer. The segregation analysis revealed that hyperpepsinogenemia I was inherited as an autosomal dominant inheritance, and in some families this trait was responsible for familial aggregation of duodenal ulcer. But in other families normopepsinogenemic I duodenal ulcer has segregated and association to pathophysiological factors of this trait was obscure. These data provide evidence that genetic factors play a role in pathogenesis of duodenal ulcer, and that hyperpepsinogenemia I is one of genetic markers of this disease.
掲載誌名
Hiroshima Journal of Medical Sciences
35巻
2号
開始ページ
171
終了ページ
175
出版年月日
1986-06
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
他の一覧