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ID 49985
本文ファイル
著者
KIYOTANI, Katsuhiro
TAKEI, Naomi
MATSUO, Yoshiyasu
キーワード
Influenza virus
Lysosomal enzyme release
Myeloperoxidase
NDC
医学
抄録(英)
Extracellular release and subsequent decrease of intracellular lysosomal enzymes of guinea pig polymorphonuclear leukocytes (PMNLs) by influenza virus were observed. Total enzyme activity was also decreased in all the enzymes assayed. After incubation of the PMNLs with influenza virus at 37°C for 20 min, the degree in decrease of total enzyme activity varied from enzyme to enzyme: 50% in myeloperoxidase (MPO), 20% in acid phosphatase, 10% in N-Ac-β-glucosaminidase and β-glucuronidase and 5% in lysozyme, respectively.
Since MPO assumed to play a critical role in chemiluminescent response of luminol-enhanced system, the dysfunction in oxidative metabolism of PMNLs induced by influenza virus seems to be attributed to intraphagosomal and/or extracellular inactivation of MPO of PMNLs during the process of direct stimulation of respiratory burst.
掲載誌名
Hiroshima Journal of Medical Sciences
36巻
2号
開始ページ
249
終了ページ
255
出版年月日
1987-06
出版者
Hiroshima Journal Medical Press
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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