このエントリーをはてなブックマークに追加
ID 49926
本文ファイル
著者
KISHIMOTO, Shinya
KOSAKA, Tatsuya
OGAWA, Mitsuyo
TAKABA, Norio
KONEMORI, Reiko
KAMBARA, Akihiko
OKAMOTO, Kazuma
SHIMIZU, Satoru
KUNITA, Toshiro
DAITOKU, Kunihiko
KAJIYAMA, Goro
キーワード
Gastric
Mucosa
MNNG
Atypism
Hyperplastic gastritis
NDC
医学
抄録(英)
The morphology of the rat gastric mucosa was examined by light microscopy after short term-administration of a carcinogenic agent, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG, at a dose of 50 mg/I in 0.04% of Tween 60), which was given to rats ad libitum from light-sealed bottles for 3 months. Tween 60 (0.04%) was given to rats as control for 3 months. Rats thus treated were sacrificed by decapitation at the end of 3 months after the beginning of the experiment. Tissue samples were taken from the area of the gastric mucosa designated before the experiment. Tissue sections three microns in thickness were stained with hematoxylin and eosin for histopathological evaluation and stained with azan for evaluation of proliferation of collagenous fiber. Slight atrophic changes, such as reduction in the number of parietal cells per unit area (78.8 ± 15.4 in the MNNG group and 110.1 ± 20.8 in the control group), shortened mucosal thickness (5.36 ± 0.69 in the MNNG group and 6.72 ± 0.53 in the control group), slight infiltration (grade 1) of inflammatory cell infiltration, and also slight proliferation (grade 1) of collagenous fibers were present in the fundic mucosa of rats treated with MNNG, while mucosal changes of hyperplastic gastritis, such as hyperplastic glands, increased mucosal thickness (2.77 ± 0.15 in the MNNG group; 2.64 ± 0.21 in the control group), and mild infiltration (grade 2) of inflammatory cells, and mild proliferation (grade 2) of collagenous fibers were present in the pyloric mucosa of rats treated with MNNG. Furthermore, in the pyloric mucosa, focal and diffuse lesions composed of atypical cells with erosions considered to be precancerous stage were present. Diffuse mucosal surface injuries (erosions) existed in both the fundic and pyloric mucosa. Development of gastric cancer does not seem to be involved in the background such as mucosa with atrophic gastritis but with hyperplastic gastritis in short term administration of MNNG.
掲載誌名
Hiroshima Journal of Medical Sciences
35巻
3号
開始ページ
237
終了ページ
243
出版年月日
1986-09
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
他の一覧