このエントリーをはてなブックマークに追加
ID 49925
本文ファイル
著者
FUJIWARA, Saeko
AKIYAMA, Mitoshi
KOBUKE, Kyoko
ICHIMARU, Shinichiro
TAKAISHI, Masatoshi
INAMIZU, Tsutomu
KOHNO, Nobuoki
TAKAMI, Shunsuke
NOUMI, Kazumasa
KAWAMOTO, Masahide
YAMAKIDO, Michio
キーワード
Lung cancer
Lymphocyte subsets
Monoclonal antibody
NDC
医学
抄録(英)
Lymphocyte subsets and lymphocyte responsiveness to mitogens were examined for patients with lung disease and healthy people. The results are as follows:
1) Lymphocytes derived from healthy persons showed an age dependent increase in the percentage of Leu-7+ cells and a decrease in reactivity to phytohemagglutinin (PHA). The percentage of Leu-1+ and Leu-3a+ cells was higher in females than in males under 30 years of age, while the percentage of Leu-7+ cells was higher in males at all ages.
2) Untreated lung cancer patients showed decreases in the percentage of Leu-1+ cells and reactivity to PHA and concanavalin A (Con A), and an increase in the percentage of Leu-11a+ cells.
3) No difference in lymphocyte subsets nor in reactivity to mitogens was observed between patients of different clinical stages. However, when the lymphocyte subsets were compared between patients at each stage and the healthy group, decreased percentages of Leu-1+ and Leu-3a+ in patients with stage IV cancer and Leu-2a+ in those with stage I were observed, while the percentage of Leu-11a+ cells was high in stage I and III patients.
4) No difference in lymphocyte subsets in relation to histological type was observed.
5) Among noncancerous respiratory disease patients, there was a reduced percentage of Leu-1+ cells in sarcoidosis and pulmonary emphysema, and reduced percentages of Leu-1+ and Leu-3a+ cells in pulmonary fibrosis and diffuse panbronchiolitis.
掲載誌名
Hiroshima Journal of Medical Sciences
35巻
3号
開始ページ
227
終了ページ
236
出版年月日
1986-09
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
他の一覧