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ID 14104
本文ファイル
著者
Inamatsu, Mutsumi
Tochio, Takumi
Makabe, Aya
Endo, Tetsuya
Oomizu, Souichi
Kobayashi, Eiji
キーワード
placode
embryonic hairs
hair germs
EGFP-transgenic rats
hair cycle
hair follicles
recombinant skin
skin transplantation
nude mice
NDC
生物科学・一般生物学
抄録(英)
Hair induction in the adult glabrous epidermis by the embryonic dermis was compared with that by the adult dermis. Recombinant skin, composed of the adult sole epidermis and the embryonic dermis containing dermal condensations (DC), was transplanted onto the back of nude mice. The epidermis of transplants formed hairs. Histology on the induction process demonstrated the formation of placode-like tissues, indicating that the transplant produces hair follicles through a mechanism similar to that underlying hair follicle development in the embryonic skin. An isolated adult rat sole skin piece, inserted with either an aggregate of cultured dermal papilla (DP) cells or an intact DP between its epidermis and dermis, was similarly transplanted. The transplant produced hair follicles. Histology showed that the epidermis in both cases surrounded the aggregates of DP cells. The epidermis never formed placode-like tissues. Thus, it was concluded that the adult epidermal cells recapitulate the embryonic process of hair follicle development when exposed to DC, whereas they get directly into the anagen of the hair cycle when exposed to DP. The expression pattern of Edar and Shh genes, and P-cadherin protein during the hair follicle development in the two types of transplants supported the above conclusion.
掲載誌名
Development, Growth and Differentiation
48巻
2号
開始ページ
73
終了ページ
86
出版年月日
2006-02
出版者
Blackwell Publishing
ISSN
0012-1592
NCID
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2006 Blackwell Publishing, Inc
関連情報URL(IsVersionOf)
http://dx.doi.org/10.1111/j.1440-169X.2006.00848.x
部局名
理学研究科