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ID 46208
本文ファイル
著者
Ikeda, Atsushi 大学院工学研究科 広大研究者総覧
Iizuka, Tatsuya
Maekubo, Naotake
Nobusawa, Kazuyuki
Sugikawa, Kouta 大学院工学研究科 広大研究者総覧
Koumoto, Kazuya
Suzuki, Toshio
Nagasaki, Takeshi
Akiyama, Motofusa
キーワード
fullerenes
host-guest chem.
macrophage
medicinal chem.
polysaccharides
NDC
化学
抄録(英)
Anionic and neutral fullerene derivatives were dissolved in water by β-(1,3-1,6)-D-glucan (β-1,3-glucan) as a solubilizing agent. In the water-solubilized complexes, the concentrations of fullerene derivatives were ca. 0.30 mM and the average particle sizes were ca. 90 nm. The β-1,3-glucan complexed fullerene derivative with a carboxylic acid was found to have higher photodynamic activity toward macrophages under visible-light irradiation (λ > 610 nm) when compared with that of other β-1,3-glucan-complexed fullerene derivatives. This result suggests that carboxylic acid moieties in the complex enhance the binding affinity with β-1,3-glucan-receptors on the surface of macrophages when β-1,3-glucan is recognized. In contrast, all β-1,3-glucan complexed fullerene derivatives showed no photodynamic activity toward HeLa cells under the same conditions.
内容記述
This work was supported by JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982).
掲載誌名
Chemistry - An Asian Journal
12巻
10号
開始ページ
1069
終了ページ
1074
出版年月日
2017-05-18
出版者
Wiley-VCH
ISSN
1861-4728
1861-471X
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
This is the peer reviewed version of the following article: A. Ikeda, T. Iizuka, N. Maekubo, K. Nobusawa, K. Sugikawa, K. Koumoto, T. Suzuki, T. Nagasaki, M. Akiyama, Water-Solubilization of Fullerene Derivatives by β-(1,3-1,6)-D-Glucan and Their Photodynamic Activities toward Macrophages, Chem.-Asian J., 12, 1069–1074, 2017, which has been published in final form at https://doi.org/10.1002/asia.201700182. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
部局名
工学研究科