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ID 46324
本文ファイル
著者
Ikeda, Atsushi 大学院工学研究科 広大研究者総覧
Ashizawa, Kengo
Tsuchiya, Yuki
Ueda, Masafumi 大学院工学研究院
Sugikawa, Kouta 大学院工学研究科 広大研究者総覧
NDC
化学
抄録(英)
Nineteen poorly water‐soluble π‐conjugated molecules were evaluated in terms of their ability to be stably incorporated into lipid membranes. The resulting lipid membrane-incorporated π‐conjugated guest molecules (LMIGs) were classified into four categories, including (i) those that formed stable LMIGs; (ii) those where some of guest molecules precipitated; (iii) those that formed small self‐aggregates consisting of lipids and/or guest molecules; and (iv) those that leaked some of the guest molecules into the bulk water. Compounds belonging to category (ii) were confirmed by UV‐vis absorption analysis. In contrast, compounds belonging to categories (i), (iii) and (iv) were discriminated based on their 1H NMR spectra and the broadening or disappearance of the peaks of the guest molecules and the lipids in LMIGs and large liposomes. Several LMIGs could be converted from one category to another using other lipids. Furthermore, the guest molecules belonging to category (iv) were successfully predicted using the octanol‐water partition coefficient, which was calculated by simulation.
内容記述
This work was supported by the Japanese Society for the Promotion of Science (JSPS) KAKENHI Grant‐in‐Aid for Scientific Research (B) (Grant No. JP16H04133) and a Grant‐in‐Aid for Challenging Exploratory Research (Grant No. JP16K13982).
掲載誌名
RSC Advances
6巻
82号
開始ページ
78505
終了ページ
78513
出版年月日
2016-08-12
出版者
Royal Society of Chemistry
ISSN
2046-2069
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
This journal is © The Royal Society of Chemistry 2016
This is the accepted manuscript of an article is available at http://dx.doi.org/10.1039/C6RA18635A.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
部局名
工学研究科