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ID 46214
著者
Shimokawa, Ryo
Ueda, Masafumi 大学院工学研究院
Sugikawa, Kouta 大学院工学研究科 広大研究者総覧
Ikeda, Atsushi 大学院工学研究科 広大研究者総覧
キーワード
Liposomes
Drug delivery
Photochemistry
Host-guest system
Dimerization
NDC
化学
抄録(英)
In a drug-delivery system using liposomes, the use of guest molecules bearing hydrophilic moieties results in some leakage from lipid membranes. We suppressed the leakage of coumarins (used as model guest molecules in a drug-delivery system) from lipid membranes by photodimerization at 365 nm. The reason for this phenomenon could be ascribed to an increase in the hydrophobicity of the dimers of the coumarins. The formation of the dimers was detected by 1H NMR, UV-vis absorption, and mass spectra and the leakage percentages of the coumarins were determined by 1H NMR spectra based on the peak intensities. In contrast, when the dimer reverted to a monomer by ultraviolet (254 nm) irradiation, the resulting monomer was released from liposomes.
内容記述
This work was supported by a JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and a Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982).
掲載誌名
Journal of Photochemistry and Photobiology B: Biology
185巻
開始ページ
235
終了ページ
240
出版年月日
2018-08
出版者
Elsevier B.V.
ISSN
1011-1344
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2018 Elsevier B.V.
This manuscript version is made available under the CC-BY-NC-ND 4.0 license. http://creativecommons.org/licenses/by-nc-nd/4.0/
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
部局名
工学研究科
備考
Post-print version/PDF may be used in an institutional repository after an embargo period of 24 months.