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ID 50424
本文ファイル
著者
Kudo, Yoshiki 大学院医系科学研究科(医) 広大研究者総覧
Koh, Iemasa 病院周産母子センター 広大研究者総覧
Yamazaki, Tomomi
Oomori, Yuriko
Sugimoto, Jun 大学院医系科学研究科(医) 広大研究者総覧
キーワード
Indoleamine 2,3-dioxygenase (IDO)
Trophoblast invasion
Decidua
Caesarean scar pregnancy
Placenta accreta spectrum (PAS)
抄録(英)
Immunohistochemical localisation of indoleamine 2,3-dioxygenase was studied in order to better understand the pathophysiology of placenta accreta spectrum. In the decidua staining for indoleamine 2,3-dioxygenase was found in the glandular epithelium with some additional positive cells. Extravillous cytotrophoblast invasion was present in the myometrium which was not covered by the decidual tissue whereas myometrial invasion of cytotrophoblasts was absent where this tissue lay deep to decidua. These results suggest that indoleamine 2,3-dioxygenase expression in the decidua may normally control trophoblast invasion and absence of its expression where decidua is absent may be involved in the pathogenesis of the over-invaded placenta.
内容記述
We are grateful to the Grant-in-Aid for Scientific Research (17K11238), Japan Society for the Promotion of Science for financial support.
掲載誌名
Journal of Reproductive Immunology
138巻
開始ページ
103099
出版年月日
2020-04
出版者
Elsevier
ISSN
0165-0378
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
関連情報URL
部局名
医系科学研究科
病院
その他
備考
Post-print version/PDF may be used in an institutional repository after an embargo period of 12 months.