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ID 48685
本文ファイル
著者
Tsuji, Mayumi
Koriyama, Chihaya
Ishihara, Yasuhiro 大学院総合科学研究科 広大研究者総覧
Yamamoto, Megumi
Yamamoto-Hanada, Kiwako
Kanatani, Kumiko
Bamai, Yu Ait
Onishi, Kazunari
Senju, Ayako
Araki, Shunsuke
Shibata, Eiji
Morokuma, Seiichi
Sanefuji, Masafumi
Kitazawa, Hiroshi
Saito, Mayako
Umezawa, Masakazu
Onoda, Atsuto
Kusuhara, Koichi
Tanaka, Rie
Kawamoto, Toshihiro
the Japan Environment & Children’s Study Group
キーワード
metal concentrations
specific IgE
pregnant women
maternal health
allergic sensitization
抄録(英)
Background: Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.
Methods: We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children’s Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second=third trimester. Concentrations of the metals Cd, Pb, Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM), Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or ≥0.35UA=mL, and the metal levels were divided into quartiles.
Results: Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations.
Conclusions: Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women.
内容記述
This work was supported by the Ministry of the Environment, Japan.
Supplementary data related to this article can be found at https://doi.org/10.2188/jea.JE20180098.
掲載誌名
Journal of Epidemiology
29巻
12号
開始ページ
478
終了ページ
486
出版年月日
2019-12-05
出版者
Japan Epidemiological Association
日本疫学会
ISSN
1349-9092
0917-5040
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright © 2019 Mayumi Tsuji et al. This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
関連情報URL
部局名
総合科学研究科
統合生命科学研究科