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ID 51516
本文ファイル
著者
Honmyo, Naruhiko
Kobayashi, Tsuyoshi 大学院医系科学研究科(医) 広大研究者総覧
Oshita, Akihiko
Onoe, Takashi
Kohashi, Toshihiko
Fukuda, Saburo
Ohmori, Ichiro
Abe, Tomoyuki
Imaoka, Yasuhiro
Akita, Tomoyuki 大学院医系科学研究科(医) 広大研究者総覧
Ohdan, Hideki 大学院医系科学研究科(医) 広大研究者総覧
抄録(英)
Background
The permissible liver resection rate for preventing posthepatectomy liver failure (PHLF) remains unclear. We aimed to develop a novel PHLF-predicting model and to strategize hepatectomy for hepatocellular carcinoma (HCC).

Methods
This retrospective study included 335 HCC patients who underwent anatomical hepatectomy at eight institutions between 2013 and 2017. Risk factors, including volume-associated liver-estimating parameters, for PHLF grade B–C were analyzed in a training set (n = 122) via multivariate analysis, and a PHLF prediction model was developed. The utility of the model was evaluated in a validation set (n = 213).

Results
Our model was based on the three independent risk factors for PHLF identified in the training set: volume-associated indocyanine green retention rate at 15 min, platelet count, and prothrombin time index (the VIPP score). The areas under the receiver operating characteristic curve of the VIPP scores for severe PHLF in the training and validation sets were 0.864 and 0.794, respectively. In both sets, the VIPP score stratified patients at risk for severe PHLF, with a score of 3 (specificity, 0.92) indicating higher risk.

Conclusion
Our model facilitates the selection of the appropriate hepatectomy procedure by providing permissible liver resection rates based on VIPP scores.
内容記述
This research was supported by the Japan Agency for Medical Research and Development (AMED, grant number JP19fk0210051) and the Japanese Society for the Promotion of Science (JSPS KAKENHI, grant number JP18K08706)
掲載誌名
HPB
23巻
1号
開始ページ
134
終了ページ
143
出版年月日
2021-01
出版者
Elsevier
ISSN
1365-182X
1477-2574
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
関連情報URL
部局名
医系科学研究科
病院
その他