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ID 48981
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著者
Minamizaki, Tomoko 大学院医系科学研究科(歯) 広大研究者総覧
Nakao, Yuko
Irie, Yasumasa
Ahmed, Faisal
Itoh, Shota
Sarmin, Nushrat
Yoshioka, Hirotaka 大学院医歯薬保健学研究院(歯)
Nobukiyo, Asako 自然科学研究支援開発センター 広大研究者総覧
Fujimoto, Chise
Niida, Shumpei
Sotomaru, Yusuke 自然科学研究支援開発センター 広大研究者総覧
Tanimoto, Kotaro 大学院医系科学研究科(歯) 広大研究者総覧
Kozai, Katsuyuki 大学院医系科学研究科(歯) 広大研究者総覧
Sugiyama, Toshie
Bonnelye, Edith
Takei, Yuichiro 大学院医歯薬保健学研究院(歯)
Yoshiko, Yuji 大学院医系科学研究科(歯) 広大研究者総覧
抄録(英)
Communication between osteoblasts and osteoclasts plays a key role in bone metabolism. We describe here an unexpected role for matrix vesicles (MVs), which bud from boneforming osteoblasts and have a well-established role in initiation of bone mineralization, in osteoclastogenesis. We show that the MV cargo miR-125b accumulates in the bone matrix, with increased accumulation in transgenic (Tg) mice overexpressing miR-125b in osteoblasts. Bone formation and osteoblasts in Tg mice are normal, but the number of bone-resorbing osteoclasts is reduced, leading to higher trabecular bone mass. miR-125b in the bone matrix targets and degrades Prdm1, a transcriptional repressor of anti-osteoclastogenic factors, in osteoclast precursors. Overexpressing miR-125b in osteoblasts abrogates bone loss in different mouse models. Our results show that the MV cargo miR-125b is a regulatory element of osteoblast-osteoclast communication, and that bone matrix provides extracellular storage of miR-125b that is functionally active in bone resorption.
内容記述
T.M. and Y.T. were supported in part by MEXT KAKENHI (JP16K11443, T.M.; JP26861548, Y.T.). Y.Y. was supported by MEXT KAKENHI (JP18K19647), the Raffinee International Foundation and the Ono Pharmaceutical Foundation.
Supplementary information is available for this paper at https://doi.org/10.1038/s42003-020-0754-2.
掲載誌名
Communications Biology
3巻
開始ページ
30
出版年月日
2020-01-16
出版者
Nature Research
ISSN
2399-3642
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
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© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
関連情報URL
部局名
医系科学研究科
医歯薬保健学研究科
自然科学研究支援開発センター