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ID 38079
本文ファイル
著者
Takesue, Yoshio
Yokoyama, Takashi
Kodama, Takashi
Sewake, Hitoshi
Miyamoto, Katsunari
Imamura, Yuuji
Tsumura, Hiroaki
Matsuura, Yuichiro
キーワード
β-lactamase
R plasmid
Antibiotic resistance
Chemotherapeutic agents
NDC
医学
抄録(英)
Concomitant with the extensive use of antibiotics, the number of multiple antibiotic-resistant strains has been increasing. Since resistance is mainly mediated by R plasmids, we undertook to investigate the characteristics of R plasmid-determined ,β-lactamase in 6 Gram-negative rods.   

The β-lactamase produced by each organism was classified by its substrate: type P which attacks penicillins, type C which attacks cephalosporins, and type C/P which attacks both penicillins and cephalosporins. Though the chromosomally mediated β-lactamase of almost all Gram-negative rods is classified as type C, R plasmid-mediated β-lactamase is almost equally active against both penicillins and cephalosporins. Therefore, we suggest that type C/P ,β-lactamase was mediated by R plasmids in Gram-negative rods which already produced chromosomally mediated type C β-lactamase.   

The strains which produced type C/P β-lactamse tended to be more resistant to antibiotics than the other β-lactamase producing strains. Among type C/P strains, the sensitivity to cephalosporins varied with the bacterial species, whereas all these strains were highly resistant to penicillins. Even for piperacillin, which is stable to cephalosporinase, the MIC at which the cumulative percentage of strains inhibited was 50% (MIC50) was over 50 μg/ml in all strains tested.
掲載誌名
Hiroshima Journal of Medical Sciences
39巻
3号
開始ページ
65
終了ページ
69
出版年月日
1990-09
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
病院
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