Mac-1 Expression and Superoxide Generation of the Peripheral Polymorphonuclear Leukocyte following Gastrectomy and Esophagectomy
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The aim of this study was to evaluate the characteristics of the polymorphonuclear leukocyte (PMN) function after surgical stress. We investigated Mac-1 expression and superoxide generation by peripheral PMNs and serum granulocyte-colony stimulating factor (G-CSF) concentrations in 15 patients who underwent either gastrectomy (n=8) or esophagectomy (n=7). The serum G-CSF rapidly increased within 24 hours after operation. The maximum levels of serum G-CSF in the cases of esophagectomy were about 5-8 fold those of gastrectomy, although the increases in PMN counts within 24 hours of esophagectomy were lower than those after gastrectomy. Mac-1 expression and superoxide generation by PMN s after gastrectomy increased significantly, in parallel with increases in the PMN counts and serum G-CSF. After esophagectomy, Mac-1 expression on peripheral PMN s remained elevated through the 7th day after operation, while superoxide generation by PMN s in response to PMA declined to below preoperative levels after the 3rd day. These results suggest that, after major surgery such as esophagectomy, there is a discrepancy between Mac-1 expression and superoxide generation by the peripheral PMN despite a high level of serum G-CSF.
Hiroshima Journal of Medical Sciences
Hiroshima University Medical Press