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ID 48710
本文ファイル
著者
Hirano, Harutoyo
Takama, Renjo
Matsumoto, Ryo
Tanaka, Hiroshi
Hirano, Hiroki
Soh, Zu 大学院工学研究科 広大研究者総覧
Ukawa, Teiji
Takayanagi, Tsuneo
Morimoto, Haruka
Nakamura, Ryuji
Hashimoto, Haruki
Matsui, Shogo
Kishimoto, Shinji 原爆放射線医科学研究所 広大研究者総覧
Oda, Nozomu
Kajikawa, Masato 病院未来医療センター 広大研究者総覧
Kawamoto, Masashi 大学院医歯薬保健学研究科(医)
Yoshizumi, Masao 大学院医歯薬保健学研究科(医) 広大研究者総覧
Higashi, Yukihito 原爆放射線医科学研究所 広大研究者総覧
Tsuji, Toshio 大学院工学研究科 広大研究者総覧
抄録(英)
This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mmHg higher than the subject’s lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release. Next, values of the proposed index, %ezFMDL, for assessing the vascular endothelial function of lower-limb arteries were determined from 327 adult subjects: 87 healthy subjects, 150 subjects at high risk of arteriosclerosis and 90 patients with cardiovascular disease (CAD). The mean values and standard deviations calculated using %ezFMDL were 30.5 ± 12.0% for the healthy subjects, 23.6 ± 12.7% for subjects at high risk of arteriosclerosis and 14.5 ± 15.4% for patients with CAD. The %ezFMDL values for the subjects at high risk of arteriosclerosis and the patients with CAD were significantly lower than those for the healthy subjects (p < 0.01). The proposed method may have potential for clinical application.
内容記述
This work was supported by JSPS KAKENHI Grant Number 16K21076.
掲載誌名
Scientific Reports
8巻
開始ページ
9263
出版年月日
2018-06-18
出版者
Nature Research
ISSN
2045-2322
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
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権利情報
© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
関連情報URL
部局名
工学研究科
医歯薬保健学研究科
病院
原爆放射線医科学研究所
その他