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ID 47664
本文ファイル
著者
Kawai, Toru
Kusano, Yoshie
Yamada, Kyouko
Ueda, Chikako
Kawai, Atsushi
キーワード
Continuous erythropoiesis receptor activator
Epoetin beta pegol
Hemoglobin
Hemodialysis
Anemia
抄録(英)
Recent evidence on maintenance administration of epoetin beta pegol, a continuous erythropoiesis receptor activator (CERA), in dialysis patients shows the clinical benefit of bi-weekly administration (Q2W) in improving hematopoiesis and iron use efficiency. We undertook a single-center observational study of 33 Japanese maintenance dialysis patients, whose anemia had been kept stable through weekly administration (Q1W) of darbepoetin (DA), to evaluate the effectiveness of CERA Q2W switched from DA in maintaining hemoglobin (Hb) levels over a 12-month period. The target Hb level was 10.0–12.0 g/dL. Throughout the 12-month period, the mean Hb was stably maintained at 10.5–10.8 g/dL, 69.7–87.9% of the patients achieving the target Hb level. The mean CERA dose was within the range of 62.9–78.8 µg/2 weeks. The average CERA dose adjustment frequency after switching was low at 0.42–0.67 times/3 months. In both subgroups stratified by the DA dose prior to the switch, Hb levels were kept stable during CERA administration; however, in the low-dose group (10–20 µg/week of DA), the CERA and iron doses decreased over time, whereas in the high-dose group (30–60 µg/week of DA) they remained unchanged. CERA Q2W achieved long-term successful anemia management in Japanese maintenance dialysis patients after switching from DA Q1W. CERA dose was adjusted based on an overall consideration of past changes in Hb levels, erythropoiesis-stimulating agent and iron doses. Subgroup analysis showed the CERA dose in the low-dose group decreased continuously, due possibly to a long-term improvement in iron use efficiency.
掲載誌名
Journal of Artificial Organs
22巻
2号
開始ページ
146
終了ページ
153
出版年月日
2018-11-14
出版者
Springer Japan
ISSN
1434-7229
1619-0904
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
© The Japanese Society for Artificial Organs 2018. The final publication is available at www.springerlink.com.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
関連情報URL
部局名
病院
備考
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