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ID 47590
本文ファイル
著者
キーワード
Aging
Klotho
Renal fibrosis
TGF-β1
Histone methylation
抄録(英)
Systemic symptoms such as the ectopic calcification, atrophy of skin and muscle, and impaired sexual function observed in chronic kidney diseases (CKD) have been reported to coincide with those observed in geriatric symptoms. Regarding the kidney, clinical/pathological characteristics in CKD patients also coincide with those in the aging kidney. These findings suggest common mechanisms in the development of both CKD and aging. Our investigation of aging factors associated with renal fibrosis in IgA nephropathy patients revealed a significant correlation between accumulation of cells with an arrested cell cycle and decreased expression of Klotho protein. Because cell cycle arrest has a protective effect on organs in the acute phase, the proposed therapeutic target against the aging process is to maintain expression of Klotho protein. In addition, it is recognized that TGF-β1 plays a central role in the development of renal fibrosis. However, TGF-β1 has also been reported to decrease expression of Klotho protein. In this report, we provide an interpretation of our new treatment strategy which involves controlling histone methylation.
内容記述
Scientific Aspects of Dialysis Therapy: JSDT/ISBP Anniversary Edition.
This work was supported by the Grant-in-Aid for Scientific Research (KAKENHI) No.16K09610 (to S.D.) in Hiroshima University.
掲載誌名
Contributions to Nephrology
189巻
開始ページ
178
終了ページ
183
出版年月日
2016-12-12
出版者
S. Karger AG, Basel.
ISSN
0302-5144
1662-2782
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
© 2017 S. Karger AG, Basel.
This is the peer-reviewed but unedited manuscript version of the following article: Contrib Nephrol. 2017;189:178-183. (DOI: 10.1159/000450776). The final, published version is available at http://www.karger.com/?doi=10.1159/000450776
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
関連情報URL
部局名
病院