A Water-soluble Extract from Culture Medium of Ganoderma lucidum Mycelia Suppresses the Development of Colorectal Adenomas
この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00034972
ID | 34972 |
本文ファイル | |
著者 |
Oka, Shiro
Ito, Masanori
|
キーワード | Ganoderma lucidum
Colorectal adenoma
Cancer prevention
Clinical trial
|
NDC |
医学
|
抄録(英) | A water-soluble extract from a cultured medium of Ganoderma lucidum mycelia (MAK) is one of the G. lucidum extracts that has been reported to show have exhibit cancer-preventive effects in the animal studies. To confirm cancer-preventive effects of MAK, we performed a no-treatment concurrent controlled trial on patients with colorectal adenomas. Patients who were determined to be carrying colorectal adenomas by colonoscopy were enrolled in this study. Patients in the MAK group took MAK (1.5 g/day) for 12 months. Follow-up colonoscopy was performed after 12 months, and the colonoscopists recorded the size, site and macroscopic type of all adenomas. Among 123 patients who enrolled in the MAK group, 96 eligible patients completed the trial. The 102 eligible patients in the no-treatment control group were selected randomly from our department's patients. The changes in the number of adenomas up to 12 months increased to 0.66 ± 0.10 (mean± SE) in the control group, while decreasing in the MAK group to -0.42 ± 0.10 (p<0.01). The total size of adenomas increased to 1.73 ± 0.28 mm in the control group and decreased to -1.40 ± 0.64 mm in the MAK group (p<0.01). The results suggest that MAK suppresses the development of colorectal adenomas - precancerous lesions of the large bowel.
|
掲載誌名 |
Hiroshima Journal of Medical Sciences
|
巻 | 59巻
|
号 | 1号
|
開始ページ | 1
|
終了ページ | 6
|
出版年月日 | 2010-03
|
出版者 | Hiroshima University Medical Press
|
ISSN | 0018-2052
|
NCID | |
言語 |
英語
|
NII資源タイプ |
紀要論文
|
広大資料タイプ |
学内刊行物(紀要等)
|
DCMIタイプ | text
|
フォーマット | application/pdf
|
著者版フラグ | publisher
|
権利情報 | (c) Hiroshima University Medical Press.
|
部局名 |
医歯薬学総合研究科
病院
保健管理センター
|
他の一覧 |