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ID 281
本文ファイル
著者
Shiraki, Katsuhisa
Lu, Huimei
Ishimura, Yoshimasa
Kashiwabara, Shoji
Uesaka, Toshihiro
Katoh, Osamu
Watanabe, Hiromitsu
キーワード
Carcinogen
Rat
Mothers milk
Tumor induction
NDC
医学
抄録(英)
In this experiment, MNU was administered, followed by MNNG, to assess effects ofsurrogate mothering on tumor. One or two day old male SD pups were treated with or without30mg/kg body weight of methylnitrosourea (MNU) and nursed by SD or ACI surrogate mothersfor 5 weeks. When 6-weeks-old they were then treated with 100ppmN-methyl-N-nitro-N-nitrosoguanidine (MNNG) or tap water for 16 weeks. The tumor incidencein the MNNG alone group was significantly lower than with MNU alone or MNU+MNNG (p<0.01).Kidney or nerve tumors mainly developed in the MNU group, gastric tumors in the MNNG group,and the two combined in the MNU+MNNG group. The incidence and mean number of tumors didnot significantly differ between the two weaning groups. However, mean survival time withthe ACI surrogate mothers after treatment with MNU was increased as compared with the SDmother group. Cumulative development of tumors in the ACI surrogate mother group was alsodelayed (p<0.05). Similar results were obtained with MNU+MNNG and MNNG alone. The presentexperiment suggested that tumor induction might be effected by components of the mother'smilk.
掲載誌名
Hiroshima Journal of Medical Sciences
51巻
3号
開始ページ
75
終了ページ
79
出版年月日
2002-09-10
出版者
Hiroshima University Medical Press
寄与者
国立情報学研究所
作成年月日
2006-03-21
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
原爆放射線医科学研究所
医歯薬学総合研究科
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