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ID 30817
本文ファイル
著者
Kashiwabara, Shoji
Kashimoto, Naoki
Uesaka, Toshihiro
Wakabayashi, Keiji
キーワード
Gastric tumor
Azoxymethane
2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine
F344 rats
Intestinal metaplasia
NDC
医学
抄録(英)
Male F344 5-week-old rats were X-irradiated, and 16 weeks after the first dose. azoxymethane (AOM) was injected or 2-amino-l-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) was given by intragastric intubation. Tumors in the pylorus of the glandular stomach were observed in 4 out of the 29 animals receiving X-rays + AOM and in 4 out of the 25 animals receiving X-rays + PhIP, 12 months after administration. No such lesions were found in the chemical or X-ray alone groups. Intestinal metaplasia and some induced tumors were positive for CDX2. It was concluded that the presence of intestinal metaplasia may increase sensitivity to the induction of gastric tumors by colon carcinogens.
掲載誌名
Journal of Experimental & Clinical Cancer Research
24巻
2号
開始ページ
305
終了ページ
312
出版年月日
2005
出版者
BioMed Central
ISSN
0392-9078
NCID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright (c) 2005 S. Kashiwabara et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
部局名
原爆放射線医科学研究所