BCR-ABL mRNA Expression in Patients with Chronic Myeloproliferative Disorders : Absence of BCR-ABL Fused Clone except Chronic Myelocytic Leukemia
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Breakpoint cluster region
Chronic myeloproliferative disorders
Bcr-abl mRNA expression was studied in patients with chronic myeloproliferative disorders (CMPD) by the reverse transcriptase-polymerase chain reaction (RT-PCR) method. A bcr-abl transcript was not found in any patient with polycythemia vera, essential thrombocythemia or primary myelofibrosis, suggesting that the bcr-abl rearranged clone is not present in CMPD other than chronic myelogenous leukemia (CML). In CML clinical and laboratory data were compared from three bcr-abl types: the bcr exon 2-abl exon 2 (B2-A2) type, bcr exon 3-abl exon 2 (B3-A2) type and the co-expression type. Age at diagnosis tended to be younger (p=0.08) in the co-expression type, and the platelet count tended to be lower (p=0.11) in the B2-A2 type. However, there was no difference in other data, including the duration of the chronic phase and the phenotype of blasts at blast crisis.
Hiroshima Journal of Medical Sciences
Hiroshima University Medical Press