このエントリーをはてなブックマークに追加
ID 37843
本文ファイル
著者
Takimoto, Yasuo
Takafuta, Toshiro
Imanaka, Fumio
Kuramoto, Atsushi
Sasaki, Naomi
Nanba, Koji
キーワード
Follicular Lymphoma
Transformation
BCL2
p53
C-MYC
NDC
医学
抄録(英)
Follicular lymphoma is a low grade malignant lymphoma. However, some follicular lymphomas undergo histological transformation into higher grade malignant lymphomas. We recently encountered a diffuse large cell lymphoma which seemed to have progressed from a follicular lymphoma and which finally transformed into a small non-cleaved lymphoma. Each stage of the histological transformation was accompanied by increasing clinical grades of malignancy. It was suspected that in our patient a follicular lymphoma initially developed due to rearrangement of the BCL2 gene, and then underwent histological transformation into a diffuse large cell lymphoma, which was associated with p53 mutation. Subsequent rearrangement of C-MYC promoted the histological transformation of this diffuse large cell lymphoma into a small non-cleaved lymphoma. Our findings indicate that p53 mutation and rearrangement of C-MYC are involved in the histological transformation of follicular lymphomas into more advanced lymphomas.
掲載誌名
Hiroshima Journal of Medical Sciences
45巻
2号
開始ページ
69
終了ページ
73
出版年月日
1996-06
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
原爆放射線医科学研究所
総合科学研究科
医歯薬学総合研究科
他の一覧