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ID 38033
本文ファイル
著者
Matsuura, Yuichiro
Matsushima, Takeshi
Mukai, Shogo
Kajihara , Hiroki
キーワード
Heterotopic cardiac transplantation
Acute cardiac rejection
Endomyocardial biopsy
NDC
医学
抄録(英)
A model of heterotopic cardiac transplantation for diagnosis of rejection is described. Heterotopic cardiac transplantations were performed in the thorax using the left innominate artery as an arterial supply with venous return into the superior vena cava. Six pairs of mongrel dogs underwent cardiac transplantation using this technique. Two dogs died postoperatively on the 2nd and 3rd day due to respiratory failure. Another four donor hearts arrested their beats in 6 to 8 postoperative days (mean 6.3 days) resulting from acute cardiac rejection. Serial echocardiographic recordings were found to be a reliable measure of acute cardiac rejection, since the left ventricular wall thickness of the donor heart increased until the donor heart stopped by rejection. Endomyocardial biopsy was easy to perform by passage of flexible cardiac biotome into the right ventricle of the donor and the recipient heart through the right internal jugular vein. Pathological findings revealed that early changes of the donor heart were interstitial edema caused by myocardial ischemia. This was followed by lymphocyte infiltration around peripheral coronary arteries and acute rejection resulting in myocyte necrosis.
内容記述
This study was presented in the seventh annual meeting of Japan Cardiac Transplantation Research, May 1989.
Financial contribution was granted by Tsuchiya Memorial Medical Foundation (President Dr. Taro Tsuchiya).
掲載誌名
Hiroshima Journal of Medical Sciences
39巻
1号
開始ページ
15
終了ページ
18
出版年月日
1990-03
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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