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ID 49938
本文ファイル
著者
NAKAMURA, Koji
NAKAMOTO, Takahisa
NIHIRA, Hiromi
FUJIMOTO, Nariaki
ITO, Akihiro
キーワード
Prolactin
MtT/F84
Accessory sexual organs
Male rats
NDC
医学
抄録(英)
A new transplantable prolactinoma, designated MtT/F84 has been serially passaged in female F344 rats. Persistently high levels of serum prolactin could be achieved in male F344 rats by MtT/F84 inoculating under the skin.
This investigation deals with the effects of hyperprolactinemia upon the accessory sexual organs of male rats during puberty. The weights and the concentrations of dihydrotestosterone (DHT) in the dorsal prostate increased significantly in rats with moderate hyperprolactinemia (756 ± 179 ng/ml), but they in rats with marked hyperprolactinemia (3612 ± 1089 ng/ml) were similar t.o those of control rats. In contrast, serum testosterone levels (0.52 ± 0/17 ng/ml) in those of hyperprolactinemic rats were significantly decreased compared to that of controls (1.11± 0.13 ng/ml).
These results suggested that the growth-promoting effect of prolactin on the rat prostate mediated through the action of androgen varied according to the degree of hyperprolactinemia.
掲載誌名
Hiroshima Journal of Medical Sciences
35巻
4号
開始ページ
321
終了ページ
324
出版年月日
1986-12
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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