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ID 110
本文ファイル
著者
Hashimoto, W.
Kitayama, S.
Kumagai, K.
Morioka, N.
Dohi, Toshihiro
キーワード
Dopamine
Levodopa
Monoamine Transporter
Norepinephrine
Serotonin
Cocaine
Parkinson's disease
NDC
医学
抄録(英)
The present study investigated the effects of levodopa, a precursor of dopamine (DA) therapeutically used for the treatment of Parkinson's disease, on DA transport in the two different systems, COS-7 cells heterologously expressing rat monoamine transporter cDNA and in monoaminergic cell lines PC12 and SK-N-SH. Levodopa enhanced uptake of [3H]DA and [3H]norepinephrine (NE) but not [3H]serotonin in the transfected COS-7 cells in a concentration-dependent manner. On the other hand, in PC12 and SK-N-SH cells where NET is functionally expressed, levodopa enhanced [3H]DA and [3H]NE uptake at low concentrations and inhibited the uptake at higher concentrations. The effects of levodopa on catecholamine transporters in the opposite direction suggest a different mechanism at the intra- and extracellular sites in a levodopa transport-dependent and independent manner.
掲載誌名
Life Sciences
76巻
14号
開始ページ
1603
終了ページ
1612
出版年月日
2005-02-18
出版者
Elsevier Inc.
ISSN
0024-3205
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2004 Elsevier Inc.
関連情報URL(IsVersionOf)
http://dx.doi.org/10.1016/j.lfs.2004.08.029
部局名
医歯薬学総合研究科