Distribution of G-Cells in the Gastric Mucosa in Peptic Ulcer
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Peroxidase antiperoxidase method
The distribution of G cells in mucosa of the resected stomachs from patients with peptic ulcer was investigated using the peroxidase-antiperoxidase immunohistochemical method. Moreover, the specimens were stained additionally with hematoxylin and eosin to determine the condition of background gastric mucosa.
G cells were present chiefly in the glandular cervix of the pyloric gland area. They were also seen in the intermediate area and, although small in number, in the area adjoining the f-line. The number of G cells per unit area in DU was three times higher than that in GU. The significant inverse relation was found between G cell density and the degree of intestinal metaplasia. And in each case, mean values of uG were estimated for unit areas on the greater and lesser curvature lines as well as the unit areas on the mid-line of the anterior and posterior walls. The G cell density was higher on the greater curvature and in the posterior wall than the other.
Hiroshima Journal of Medical Sciences
Hiroshima University School of Medicine