Genetic alterations of Wnt signal components in cancer cells
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ID | 102 |
本文ファイル | |
著者 |
Kikuchi, Akira
Kinshasa, S.
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キーワード | Wnt
β-catenin
APC
Axin
Tcf
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NDC |
医学
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抄録(英) | The genetics of development and cancer have converged in the identification of intra- and extra-cellular signaling pathways that are aberrantly regulated in cancer and are also central to embryonic patterning. The Wnt signaling pathway has provided an outstanding example of this. The genes for β-catenin, APC, and Axin in the Wnt signaling pathway are often mutated in human cancers. In all such cases, the common denominator is the accumulation of cytosolic and nuclear β-catenin and the activation of transcriptional factor Tcf/Lef. The resulting gene expression profile should provide a significant clue as to cancers carrying defects in the Wnt signaling pathway. In this review, the regulation of the β-catenin stability by Axin and APC, and their genetic alterations in human cancers are described.
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掲載誌名 |
Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry
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開始ページ | 101
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終了ページ | 106
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出版年月日 | 2006-01-08
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言語 |
英語
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NII資源タイプ |
会議発表論文
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広大資料タイプ |
会議発表論文
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | publisher
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関連情報URL(isPartOf) | http://ir.lib.hiroshima-u.ac.jp/meta-bin/mt-pdetail.cgi?smode=1&edm=0&tlang=1&cd=00014842
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部局名 |
医歯薬学総合研究科
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