In vitro organogenesis using amphibian pluripotential cells
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ID | 101 |
本文ファイル | |
著者 |
Asashima, Makoto
Okabayashi, K.
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キーワード | activin
organogenesis
animal cap
mesoderm induction
organizer
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NDC |
医学
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抄録(英) | In the embryonic development of vertebrate, sequential cleavage is followed by the gastrulation as the first dynamic event of morphogenesis. Mesodermal induction is the most important event for normal body patterning such as the gastrulation, neural induction and formation of various organs. In the study to search for the mesodermal inducing factor, we reported "activin" as a strong mesoderm-inducible factor by the "animal cap assay", the in vitro assay system using amphibian pluripotential cell mass. We found that activin has mesodemal and endodermal inducing activity in dose-dependent manner, and then established the invitro induction system for various types of tissues and organs including craniofacial cartilage from animal cap cells by the treatments with activin and other inducing factors. Embryonic transplantation method showed that the treatments of animal cap cells for the induction of pronephros, beating heart were able to induce normally functional organs in vitro. These in vitro induction methods are useful for investigation of the molecular mechanisms of organ formation and body patterning in vertebrate development.
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掲載誌名 |
Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry
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開始ページ | 95
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終了ページ | 100
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出版年月日 | 2006-01-08
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言語 |
英語
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NII資源タイプ |
会議発表論文
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広大資料タイプ |
会議発表論文
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | publisher
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関連情報URL(isPartOf) | http://ir.lib.hiroshima-u.ac.jp/meta-bin/mt-pdetail.cgi?smode=1&edm=0&tlang=1&cd=00014842
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部局名 |
医歯薬学総合研究科
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