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ID 39063
本文ファイル
著者
Karki, Prasanna
Hirano, Hirofumi
Yamahata, Hitoshi
Fujio, Shingo
Yonezawa, Hajime
Bohara, Manoj
Oyoshi, Tatsuki
Hanaya, Ryosuke
Arita, Kazunori
キーワード
Langerhans cell histiocytosis
Skull
Immunostaining
Histology
NDC
医学
抄録(英)
Langerhans cell histiocytosis (LCH) is a proliferation of Langerhans cells intermixed with inflammatory cells, in particular eosinophils, that may manifest as a unisystem (unifocal or multifocal) or multisystem disease. We describe the clinical and histologic spectrum of LCH of the orbit and skull in our two cases. Both cases had unifocal erosive skull lesions with a history of trauma. Typical histologic features included numerous histiocytes with varying degrees of giant cell formation and scattered eosinophilic granulocytes. The presence of Langerhans cells was confirmed by CD1a and S100 immunohistochemistry. LCH has an excellent prognosis when treated with surgical resection, steroids and radiotherapy or chemotherapy. One of our patients is disease free at 7 year follow-up and one patient had regression of lesion on follow-up.
掲載誌名
Hiroshima Journal of Medical Sciences
64巻
4号
開始ページ
59
終了ページ
63
出版年月日
2015-12
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Hiroshima University Medical Press
部局名
医歯薬保健学研究科
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