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ID 48678
本文ファイル
著者
Saiki, Akiko 大学院医歯薬保健学研究科(医)
Kimura, Rie
Samura, Toshikazu
Yoko, Fujiwara-Tsukamoto
Sakai, Yutaka
Isomura, Yoshikazu
抄録(英)
Rodents have primary and secondary motor cortices that are involved in the execution of voluntary movements via their direct and parallel projections to the spinal cord. However, it is unclear whether the rodent secondary motor cortex has any motor function distinct from the primary motor cortex to properly control voluntary movements. In the present study, we quantitatively examined neuronal activity in the caudal forelimb area (CFA) of the primary motor cortex and rostral forelimb area (RFA) of the secondary motor cortex in head-fixed rats performing forelimb movements (pushing, holding, and pulling a lever). We found virtually no major differences between CFA and RFA neurons, regardless of neuron subtypes, not only in their basal spiking properties but also in the time-course, amplitude, and direction preference of their functional activation for simple forelimb movements. However, the RFA neurons, as compared with the CFA neurons, showed obviously a greater susceptibility of their functional activation to an alteration in a behavioral situation, a 'rewarding' response that leads to reward or a 'consummatory' response that follows reward water, which might be accompanied by some internal adaptations without affecting the motor outputs. Our results suggest that, although the CFA and RFA neurons commonly process fundamental motor information to properly control forelimb movements, the RFA neurons may be functionally differentiated to integrate motor information with internal state information for an adaptation to goal-directed behaviors.
内容記述
This work was supported by JST CREST (Y.I.), Grants-in-Aid for Scientific Research on Innovative Areas (Y.I., 22120520, 24120715) and for Scientific Research (B) (Y.I., 24300143) from MEXT, and research grants from the Uehara Memorial Foundation (Y.I.) and Brain Science Foundation (Y.I.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
掲載誌名
PLoS ONE
9巻
6号
開始ページ
e98662
出版年月日
2014-06-03
出版者
Public Library of Science
ISSN
1932-6203
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
© 2014 Saiki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
関連情報URL
部局名
医歯薬保健学研究科